- New York Mets traded Chico Fernandez and Bobby Catton to the Chicago White Sox for Charley Smith on April 23, 1964.
- New York Mets traded Frank Lary to the Chicago White Sox for Jimmie Schaffer on July 8, 1965.
- New York Mets purchased Jack Lamabe from the Chicago White Sox on April 26, 1967.
- New York Mets traded Ken Boyer and Sandy Alomar to the Chicago White Sox for J.C. Martin and Bill Southworth on July 22, 1967.
- New York Mets traded Jack Fisher, Tommy Davis, Billy Wynne and Buddy Booker to the Chicago White Sox for Tommie Agee and Al Weis on December 15, 1967.
- New York Mets traded Jesse Anderson to the Chicago White Sox for Claudell Washington on June 7, 1980.
- New York Mets signed free agent Dick Tidrow of the Chicago White Sox on January 27, 1984.
- New York Mets traded Ken Reed and Gene Autry to the Chicago White Sox for Randy Niemann on March 30, 1985.
- New York Mets traded Dave Cochrane to the Chicago White Sox for Tom Paciorek on July 16, 1985.
- New York Mets claimed Daryl Boston on waivers from the Chicago White Sox on April 30, 1990.
- New York Mets signed free agent Rodney McCray of the Chicago White Sox on December 13, 1991.
- Chicago White Sox signed Barry Jones of the New York Mets as a free agent on January 2, 1993.
- Chicago White Sox signed Darrin Jackson of the New York Mets as a free agent on December 28, 1993.
- New York Mets signed free agent Lance Johnson of the Chicago White Sox on December 14, 1995.
- New York Mets signed free agent Robin Ventura of the Chicago White Sox on December 2, 1998.
- New York Mets traded Roberto Alomar to the Chicago White Sox for Royce Ring, Edwin Almonte and Andrew Salvo on July 1, 2003.
- New York Mets traded Timo Perez to the Chicago White Sox for Matt Ginter on March 27, 2004.
- New York Mets claimed Wilson Valdez on waivers from the Chicago White Sox on March 30, 2005.
- New York Mets traded Ramon Castro to the Chicago White Sox for Lance Broadway on May 30, 2009.
- New York Mets claimed Jack Egbert on waivers from the Chicago White Sox on September 25, 2009.
- Chicago White Sox signed J.J. Putz of the New York Mets as a free agent on December 11, 2009.
- New York Mets claimed Chris Beck on waivers from the Chicago White Sox on June 13, 2018.
- New York Mets signed free agent Hector Santiago of the Chicago White Sox on January 11, 2019.
- Chicago White Sox signed Hector Santiago of the New York Mets as a free agent on June 20, 2019.
- New York Mets signed free agent Ryan Cordell of the Chicago White Sox on January 9, 2020.
- New York Mets signed free agent James McCann of the Chicago White Sox on December 15, 2020.
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